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Mentors

Name Research Description

Danielle Benoit

Synthetic hydrogels with tunable degradation and mechanical properties as a synthetic extracellular matrix analogue for the culture and delivery of cells for regenerative medicine approaches and polymers formed using reversible-addition fragmentation chain transfer polymerization (RAFT), a controlled, living polymerization strategy, designed with drug delivery applications in mind.

Benoit Biteau

Molecular and Cellular Mechanisms that Control Tissue Homeostasis and Somatic Stem Cells

Edward Brown

Multiphoton Laser Scanning Microscopy, novel in vivo imaging and measurement techniques, tumor biology, angiogenesis

Deborah A. Cory-Slechta

Defining the impact of environmental chemicals (e.g., metals and air pollution) on brain development and behavior, with emphasis on attributable risk to neurodevelopmental disorders.

Lisa DeLouise

Understanding the toxicological and biochemical properties of nanomaterial interactions with skin and the immune system; develop in vivo models to investigate nanoparticle skin penetration mechanisms, and develop novel biosensors to improve transdermal drug delivery and tissue engineering approaches.

Stephen Dewhurst

 Influenza Viruses; Virus Polymerase HIV Vaccine Development; NeuroAIDS Research

Marvin M. Doyley

Projects are underway to develop advanced ultrasonic, optical, and magnetic resonance imaging methods. These techniques are built on mechanics, inverse problems, signal and image processing, and fast computational techniques.

Michelle Dziejman

Type Three Secretion System mediated pathogenesis of V. cholerae 

 

Alison Elder

Defining the impact of inhaled ambient and workplace nano-/ultrafine particle-containing aerosols on the lung, cardiovascular system, and central nervous system, and defining the toxicological properties of the particles that are associated with a response.

 

Fabeha Fazal

A major focus of research in my laboratory deals with understanding the role and regulation of actin-myosin interactions in endothelial cell (EC) inflammation, permeability, and apoptosis, especially in the settings of acute and chronic lung injury.

Deborah Fowell

Differentiation of CD4 T lymphocytes in infectious and autoimmune disease

John Frelinger

Immunity to Tumor Antigens

Harris Gelbard

Molecular mechanisms and potential pharmacological and gene therapeutic interventions for neurologic disease associated with HIV-1 infection of the central nervous system.

Steve N. Georas

Defining the role of environmental exposures on innate and adaptive immunity in asthma and other chronic lung diseases, with an emphasis on how particulate matter and endocrine disruptors act as risk factors

Scott Gerber

Dr. Gerber is a tumor immunologist whose laboratory focuses on harnessing the immune system to recognize and kill cancerous cells. His lab uses an immunotherapeutic approach to enhance the efficacy of chemo/radiotherapies to treat both primary and metastatic malignancies. He is also the Co-Director of the Center for Tumor Immunology Research

Steven Gill

Microbial pathogens and the impact of human microbial flora on human health and disease

Marc W. Halterman

To define the transcriptional programs driving selective vulnerability and delayed neuron loss after stroke

Jeffrey Hayes

DNA structure; chromatin; protein-DNA interactions

Kirsi Jarvinen-Seppo

Food allergies disorders, caused by milk, eggs and peanuts

Minsoo Kim

Dynamic regulation of leukocyte adhesion and migration

James Kobie

Through the development of high throughput and high resolution technologies the lab dissects the mechanisms of protective and pathogenic B cell and antibody responses to advance vaccine development and disease therapeutics.

B Paige Lawrence

Delineating mechanisms by which environmental exposures during different life stages alter immune function; discovering how environmental factors modulate epigenetic programming of the developing immune system, and the consequences of these changes on susceptibility to infectious, allergic, or autoimmune disease later in life

Xin Li

Our research is to define the RNA functions in reproduction and transgenerational epigenetic inheritance

Edith M. Lord

Cell Mediated Immunity to Tumors

Sanjay B. Maggirwar

Platelets, HIV, and inflammation

 

Ania Majewska

Glia-neuron interactions during synaptic plasticity in health and disease

Thomas Mariani

Systems Biology of Lung Development and Disease

 

David H. Mathews

Computational biology of RNA, including structure prediction, molecular dynamics, and genomics

James McGrath

Cell Motility, and Quantitative light microscopy

Craig Morrell

Function of Platelets: Hemostastis/Thrombosis and Immune Regulatory Function

Tim Mosmann

The regulation of cytokine responses of human and mouse T-cell subsets in infections asthma, allergy and autoimmunity

Joshua Munger

Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation

Keith Nehrke

Integrative Physiology

M. Kerry O'Banion

Defining neuro-inflammatory processes that contribute to pathology and disease progression in Alzheimer's disease, as well as late CNS effects following radiation exposure

Michael O’Reilly

Understanding how an aberrant oxygen environment at birth disrupts development of the lung and heart, leading to persistent functional changes over the lifespan

Catherine Ovitt

Analysis of Genes Involved in Salivary Gland Function

Martin Pavelka

Biosynthesis of the Cell Wall of Mycobacterium tuberculosis; Biodefense Research

Douglas S. Portman

Neural circuit development and function; Genetic control of behavior; Sex differences in neurobiology

Christoph Proschel

Defining roles of glial progenitor cells and astrocytes as critical modulators in responses to chemical exposure, injury, or stress; discovering how exogenous factors contribute to neurodegenerative diseases; and developing new approaches to treat traumatic injury and neurodegenerative diseases

Robert Quivey

The bacterium, Streptococcus mutans, which colonizes the human mouth from the time of tooth eruption until death

Arshad Rahman

Determining how exogenous agents change lung microvasculature permeability, leading to pulmonary inflammation

Matthew Rand

Mechanisms of toxicity of the environmental contaminant and neurotoxicant methylmercury (MeHg), defining MeHg effects on early life development of neural and muscular systems at the molecular, cellular, and organismal levels using invertebrate and mammalian models, and detailed characterization of MeHg metabolism and elimination kinetics in humans

Jacques Robert

Using a comparative biology approach to advance immunotoxicology, leveraging the amphibian Xenopus and the pox-like ranavirus FV3, to address long-term effects of water pollutants on immune cell development and on antiviral immunity across the lifespan

Andrea Sant

Influenza specific immunity, vaccine design and regulation of T cell responses to pathogens.

Giovanni Schifitto

Development and implementation of novel neuroimaging biomarkers applied in the investigation and treatment of, neuroinflammatory, neurodegenerative and cerebrovascular disorders.

Patricia Sime

Conducting clinical and translational toxicology research focusing on the lung, from studies of silica and radiation in lung fibrosis, to the effects of biomass and cigarette smoke exposure on lung inflammation and resolution pathways, to identifying key pathophysiologic pathways and developing novel therapeutics for lung inflammation and fibrosis

Eric M. Small

Understanding how a cell can interpret biomechanical and humoral signals and activate a discrete transcriptional program during development or in response to injury

Martha Susiarjo

Studying epigenetic mechanisms underlying environment-induced adverse pregnancy and developmental outcomes, including how endocrine-disrupting chemicals change maternal health, mammalian reproduction, and the expression and function of imprinted genes

 

Toru Takimoto

Molecular Mechanisms of Paramyxovirus Infection, Replication and Assembly

Juilee Thakar

Identification of immune signatures and characterization of dynamics of immune responses by using systems biology approaches

David Topham

Conducting clinical and translational research on respiratory pathogens, immunity, and infectious disease, including the study of environmental factors that affect immune responses to influenza and vaccination, seeking new approaches to enhance immunity, reduce pathology, and prevent disease

Peng Yao

Pathophysiological function of microRNAs, RNA-binding proteins, and defects in protein synthesis in cardiovascular disease; RNA riboswitch-like mechanisms of gene regulation

Felix Yarovinsky

Innate immunity, Host-microbial interactions, Immunoparasitology, Mucosal immunology